Volume 26, Issue 2, September 2016, Pages 429–434
Muhammad Fiaz Khalid1, Junaid Ali Khan2, Amtul Fiaz3, Sidra Altaf4, Zainab Kaleem5, and Faiza Hassan6
1 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
2 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
3 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
4 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
5 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
6 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cefuroxime was evaluated for the pharmacokinetics and clinical effects in 8 healthy volunteers, Bolus i.v. injections of cefuroxime 750 mg b.i.d. or 750 mg once daily were given to the patients depending on the degree of renal impairment. The concentration of drug in urine was measured during treatment, and pharmacokinetic parameters were investigated; Drug elimination half-life increased from 4.2 h (creatinine clearance 23.0 ml/min) to 22.3 h (creatinine clearance 5.0 ml/min) with decreasing renal function. The apparent volume of distribution ranged from 11.6 to 17.9 . A linear correlation was found between the total and renal clearance of cefuroxime and the creatinine clearance; the extrarenal clearance was 8.24 ml/min. Concomitant treatment with furosemide did not impair renal function and no evidence of nephrotoxicity was found. The clinical efficacy of the drug was good. Symptoms of infection subsided after 3-4 days and the isolated pathogens were eradicated. No relapse or episodes of reinfection were observed in a following-up period of 3 months. The drug was well tolerated and no side effects or changes in haematological or biochemical values were seen.
Author Keywords: Renal clearance, urinary excretion, cefuroxime.
Muhammad Fiaz Khalid1, Junaid Ali Khan2, Amtul Fiaz3, Sidra Altaf4, Zainab Kaleem5, and Faiza Hassan6
1 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
2 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
3 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
4 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
5 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
6 Institute of Pharmacy, Physiology and Pharmacology, Faisalabad, Pakistan
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Cefuroxime was evaluated for the pharmacokinetics and clinical effects in 8 healthy volunteers, Bolus i.v. injections of cefuroxime 750 mg b.i.d. or 750 mg once daily were given to the patients depending on the degree of renal impairment. The concentration of drug in urine was measured during treatment, and pharmacokinetic parameters were investigated; Drug elimination half-life increased from 4.2 h (creatinine clearance 23.0 ml/min) to 22.3 h (creatinine clearance 5.0 ml/min) with decreasing renal function. The apparent volume of distribution ranged from 11.6 to 17.9 . A linear correlation was found between the total and renal clearance of cefuroxime and the creatinine clearance; the extrarenal clearance was 8.24 ml/min. Concomitant treatment with furosemide did not impair renal function and no evidence of nephrotoxicity was found. The clinical efficacy of the drug was good. Symptoms of infection subsided after 3-4 days and the isolated pathogens were eradicated. No relapse or episodes of reinfection were observed in a following-up period of 3 months. The drug was well tolerated and no side effects or changes in haematological or biochemical values were seen.
Author Keywords: Renal clearance, urinary excretion, cefuroxime.
How to Cite this Article
Muhammad Fiaz Khalid, Junaid Ali Khan, Amtul Fiaz, Sidra Altaf, Zainab Kaleem, and Faiza Hassan, “Renal clearance and urinary excretion of cefuroxime in healthy male volunteers,” International Journal of Innovation and Scientific Research, vol. 26, no. 2, pp. 429–434, September 2016.
