[ Tumeur de la granulosa adulte de l’ovaire associée à un polype de l’endomètre : quelle sont les caractéristiques anatomo-cliniques de cette association ? ]
Volume 21, Issue 2, April 2016, Pages 270–274
Abdelkader Akharraz1, Farid Kassidi2, Abdelghani Zazi3, Jaouad Kouach4, Driss Moussaoui5, and Mohammed Dehayni6
1 Service de Gynécologie et d’Obstétrique, Hôpital Militaire d’Instruction Mohamed V, Rabat, maroc
2 Department of Gynecology-Obstetric, Military Training Hospital Med V, Rabat, Morocco
3 Gynécologie - Obstétrique, Hôpital Militaire Instructif Mohamed V, Rabat, Morocco
4 Faculté de Médecine et de Pharmacie, Université Mohamed V, Rabat, Morocco
5 Department of Gynecology-Obstetric, Military Training Hospital Med V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
6 Department of Gynecology-Obstetric, Military Training Hospital Med V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Granulosa tumors of the ovary are among the rare ovarian tumors, and included in the sex cord-stromal tumor category. They have a low degree of malignancy and have a good prognosis. Their clinical presentation is sometimes suggestive. Some biological markers (serum inhibin B and AMH) may be helpful for diagnosis, though their sensitivity is not perfect. Preoperative imaging diagnosis remains challenging due to the wide variability in morphology and lack of epidemiological data in the literature. These tumors are accompanied by high levels of estrogen. This state of hyperestrogenism is responsible for a broad spectrum of endometrial pathology from simple endometrial hyperplasia to the development of adenocarcinoma of the endometrium. Through this clinical observation of tumor of the adult type granulosa, we will discuss the main clinicopathological characteristics and histogenesis of this association to improve treatment of these tumors.
Author Keywords: ovarian tumor, granulosa cell, situation of hyperetrogenism, endometrial pathology, prognosis.
Volume 21, Issue 2, April 2016, Pages 270–274
Abdelkader Akharraz1, Farid Kassidi2, Abdelghani Zazi3, Jaouad Kouach4, Driss Moussaoui5, and Mohammed Dehayni6
1 Service de Gynécologie et d’Obstétrique, Hôpital Militaire d’Instruction Mohamed V, Rabat, maroc
2 Department of Gynecology-Obstetric, Military Training Hospital Med V, Rabat, Morocco
3 Gynécologie - Obstétrique, Hôpital Militaire Instructif Mohamed V, Rabat, Morocco
4 Faculté de Médecine et de Pharmacie, Université Mohamed V, Rabat, Morocco
5 Department of Gynecology-Obstetric, Military Training Hospital Med V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
6 Department of Gynecology-Obstetric, Military Training Hospital Med V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Granulosa tumors of the ovary are among the rare ovarian tumors, and included in the sex cord-stromal tumor category. They have a low degree of malignancy and have a good prognosis. Their clinical presentation is sometimes suggestive. Some biological markers (serum inhibin B and AMH) may be helpful for diagnosis, though their sensitivity is not perfect. Preoperative imaging diagnosis remains challenging due to the wide variability in morphology and lack of epidemiological data in the literature. These tumors are accompanied by high levels of estrogen. This state of hyperestrogenism is responsible for a broad spectrum of endometrial pathology from simple endometrial hyperplasia to the development of adenocarcinoma of the endometrium. Through this clinical observation of tumor of the adult type granulosa, we will discuss the main clinicopathological characteristics and histogenesis of this association to improve treatment of these tumors.
Author Keywords: ovarian tumor, granulosa cell, situation of hyperetrogenism, endometrial pathology, prognosis.
Abstract: (french)
Les tumeurs de la Granulosa de l’ovaire font partie des tumeurs rares de l’ovaire, du groupe des tumeurs des cordons sexuels et du stroma, hormono-sécrétantes. Elles ont un faible degré de malignité et sont de bon pronostic. Leur symptomatologie clinique est parfois évocatrice. Certains marqueurs biologiques (inhibine B et AMH) peuvent être informatifs pour le diagnostic mais ils ont une sensibilité encore imparfaite. Le diagnostic préopératoire en imagerie est un challenge, compte tenu de leur grande variabilité morphologique et du manque de données épidémiologiques et séméiologiques dans la littérature. Ces tumeurs s’accompagnent d’un taux élevé d’œstrogènes. Cet état d’hyperœstrogénie est responsable d’un large spectre de pathologie endométriale allant de la simple hyperplasie de l’endomètre jusqu’au développement d’un adénocarcinome de l’endomètre. À travers une observation clinique de tumeur de la granulosa de type adulte, nous discuterons les principales caractéristiques anatomo-cliniques ainsi que l’histogenèse de cette association afin d’améliorer la prise en charge de ces tumeurs
Author Keywords: tumeur ovarienne, cellules de granulosa, terrain d’hyperoetrogénie, pathologie endométriale, pronostic.
How to Cite this Article
Abdelkader Akharraz, Farid Kassidi, Abdelghani Zazi, Jaouad Kouach, Driss Moussaoui, and Mohammed Dehayni, “Adult granulosa cell tumors of the ovary associated to endometrial polyp: what are the clinicopathological characteristics of this association?,” International Journal of Innovation and Scientific Research, vol. 21, no. 2, pp. 270–274, April 2016.
