Volume 20, Issue 1, January 2016, Pages 171–179
Brunel Monic ANGOUNDA1, Amélia BOKILO DZIA2, Fabien Roch NIAMA3, Gabriel AHOMBO4, Luc Magloire Anicet Boumba5, Donatien MOUKASSA6, Moulay Mustapha Ennaji7, and Jean-Rosaire IBARA8
1 Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, Congo
2 Faculté des Sciences et de la Santé, Université Marien NGOUABI, Brazzaville, Congo
3 Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, Congo
4 Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, Congo
5 Laboratoire de Virologie, Microbiologie et Qualité/Eco-toxicologie et biodiversité, Faculté des Sciences et Techniques Mohammedia, Université Hassan II, Mohammedia-Casablanca, BP: 146 Mohammedia 20650, Maroc
6 Laboratoire d'Analyses Médicales et Morphologiques, Hôpital Général de Loandjili, B.P. 8122, Pointe-Noire, Congo
7 Laboratoire de Virologie, Microbiologie et Qualité/Eco-toxicologie et biodiversité, Faculté des Sciences et Techniques Mohammedia, Université Hassan II, Mohammedia-Casablanca, BP: 146 Mohammedia 20650, Morocco
8 Faculté des Sciences et de la Santé, Université Marien NGOUABI, Brazzaville, Democratic Republic of the Congo
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In Congo, it is estimated that between 9 to 11% of the general population present hepatitis B surface antigen (HBsAg). Little data are available on the seroprevalence of markers and risk factors for this virus in blood donors in Brazzaville. This study aimed to determine the prevalence markers and factors associated with HBV infection in blood donors.
Six hundred and forty eight healthy blood donors samples collected from October 2013 to June 2014 were tested by enzyme-linked immunosorbent assay for HBsAg, HBeAg, anti-HBe, anti-HBs and anti-HBc. Demographic data of these donors was also studied.
Out of 648 patients included, overall prevalence estimates were 6,6%(95%CI:4.8-8.8) for HBsAg, 1,1%(95%CI:0.3-2) for HBeAg, 8.2%(95%CI:6.2-10.5) for anti-HBe, 13.6%(95%CI:11-16.4) for anti-HBs and 62.7%(95%CI:59-66.2) for anti-HBc. HBV infection was significant associated with Categories of blood donors (adjusted OR=1.70; 95%CI:1.08-2.67), age (adjusted OR=17.61; 95%CI:9.67-32.02), occupation (adjusted OR=2.25; 95%CI:1.53-3.31), sexual risk (adjusted OR=6.14; 95%CI:2.42-15.61) and families with a history HBV (adjusted OR=5.87; 95%CI:2.68-12.85).
The seroprevalence rates found in this study were higher than those in other countries, suggesting high rates of HBV infection and a persistent risk of transmission of HBV in blood donors in Brazzaville.
Author Keywords: Prevalence, Hepatitis B virus, risk factors, blood donors, Brazzaville.
Brunel Monic ANGOUNDA1, Amélia BOKILO DZIA2, Fabien Roch NIAMA3, Gabriel AHOMBO4, Luc Magloire Anicet Boumba5, Donatien MOUKASSA6, Moulay Mustapha Ennaji7, and Jean-Rosaire IBARA8
1 Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, Congo
2 Faculté des Sciences et de la Santé, Université Marien NGOUABI, Brazzaville, Congo
3 Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, Congo
4 Laboratoire de Biologie Cellulaire et Moléculaire, Faculté des Sciences et Techniques, Université Marien NGOUABI, Brazzaville, Congo
5 Laboratoire de Virologie, Microbiologie et Qualité/Eco-toxicologie et biodiversité, Faculté des Sciences et Techniques Mohammedia, Université Hassan II, Mohammedia-Casablanca, BP: 146 Mohammedia 20650, Maroc
6 Laboratoire d'Analyses Médicales et Morphologiques, Hôpital Général de Loandjili, B.P. 8122, Pointe-Noire, Congo
7 Laboratoire de Virologie, Microbiologie et Qualité/Eco-toxicologie et biodiversité, Faculté des Sciences et Techniques Mohammedia, Université Hassan II, Mohammedia-Casablanca, BP: 146 Mohammedia 20650, Morocco
8 Faculté des Sciences et de la Santé, Université Marien NGOUABI, Brazzaville, Democratic Republic of the Congo
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In Congo, it is estimated that between 9 to 11% of the general population present hepatitis B surface antigen (HBsAg). Little data are available on the seroprevalence of markers and risk factors for this virus in blood donors in Brazzaville. This study aimed to determine the prevalence markers and factors associated with HBV infection in blood donors.
Six hundred and forty eight healthy blood donors samples collected from October 2013 to June 2014 were tested by enzyme-linked immunosorbent assay for HBsAg, HBeAg, anti-HBe, anti-HBs and anti-HBc. Demographic data of these donors was also studied.
Out of 648 patients included, overall prevalence estimates were 6,6%(95%CI:4.8-8.8) for HBsAg, 1,1%(95%CI:0.3-2) for HBeAg, 8.2%(95%CI:6.2-10.5) for anti-HBe, 13.6%(95%CI:11-16.4) for anti-HBs and 62.7%(95%CI:59-66.2) for anti-HBc. HBV infection was significant associated with Categories of blood donors (adjusted OR=1.70; 95%CI:1.08-2.67), age (adjusted OR=17.61; 95%CI:9.67-32.02), occupation (adjusted OR=2.25; 95%CI:1.53-3.31), sexual risk (adjusted OR=6.14; 95%CI:2.42-15.61) and families with a history HBV (adjusted OR=5.87; 95%CI:2.68-12.85).
The seroprevalence rates found in this study were higher than those in other countries, suggesting high rates of HBV infection and a persistent risk of transmission of HBV in blood donors in Brazzaville.
Author Keywords: Prevalence, Hepatitis B virus, risk factors, blood donors, Brazzaville.
How to Cite this Article
Brunel Monic ANGOUNDA, Amélia BOKILO DZIA, Fabien Roch NIAMA, Gabriel AHOMBO, Luc Magloire Anicet Boumba, Donatien MOUKASSA, Moulay Mustapha Ennaji, and Jean-Rosaire IBARA, “Seroprevalence of markers and Risk factors of Hepatitis B Virus among blood donors in Brazzaville, Congo,” International Journal of Innovation and Scientific Research, vol. 20, no. 1, pp. 171–179, January 2016.
