Volume 12, Issue 2, December 2014, Pages 420–435
Md. Taifur Rahaman Shanju1, Md. Jalal Uddin2, Md. Riaz Murshed Chy3, and Mahbub E. Sobhani4
1 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
2 Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna-9208, Bangladesh
3 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
4 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Chronic Stress plays a significant role in the progression of tumor angiogenesis through the secretion of Catecholamines, which take part in increased production of IL-6 & VEGF. Chronic psychological stress induces secretion of catecolamines such as epinephrine (E) & noreepinephrine (NE) from adrenal medulla & sympathetic neurons which activate β-adrenergic receptors on tumor cells, which in turn enhances increased production of IL-6. IL-6 then plays a significant role in VEGF production through STAT3 activation. Il-6 follows a series of signaling cascades including cAMP/PKA & MAPK. NF-kB activation through MEK/ERK is crucial for IL-6 production. Angiogenesis, the formation of new blood vessels from preexisting vasculatures is mediated by VEGF. It also takes part in cell proliferation, cell migration & vasculogenesis, thus leading to tumor angiogenesis. The aim of this study was to know the relationship between chronic stress and tumor angiogenesis and to highlight the therapeutic point where further works may proceed on.
Author Keywords: Angiogenesis, Therapeutic, Catecholamines, Epinephrine, Noreepinephrine, Cell Proliferation, Cell Migration and Vasculogenesis.
Md. Taifur Rahaman Shanju1, Md. Jalal Uddin2, Md. Riaz Murshed Chy3, and Mahbub E. Sobhani4
1 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
2 Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna-9208, Bangladesh
3 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
4 Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna-9208, Bangladesh
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Chronic Stress plays a significant role in the progression of tumor angiogenesis through the secretion of Catecholamines, which take part in increased production of IL-6 & VEGF. Chronic psychological stress induces secretion of catecolamines such as epinephrine (E) & noreepinephrine (NE) from adrenal medulla & sympathetic neurons which activate β-adrenergic receptors on tumor cells, which in turn enhances increased production of IL-6. IL-6 then plays a significant role in VEGF production through STAT3 activation. Il-6 follows a series of signaling cascades including cAMP/PKA & MAPK. NF-kB activation through MEK/ERK is crucial for IL-6 production. Angiogenesis, the formation of new blood vessels from preexisting vasculatures is mediated by VEGF. It also takes part in cell proliferation, cell migration & vasculogenesis, thus leading to tumor angiogenesis. The aim of this study was to know the relationship between chronic stress and tumor angiogenesis and to highlight the therapeutic point where further works may proceed on.
Author Keywords: Angiogenesis, Therapeutic, Catecholamines, Epinephrine, Noreepinephrine, Cell Proliferation, Cell Migration and Vasculogenesis.
How to Cite this Article
Md. Taifur Rahaman Shanju, Md. Jalal Uddin, Md. Riaz Murshed Chy, and Mahbub E. Sobhani, “A Review on Chronic Stress Mediated Tumor Angiogenesis through IL-6 & VEGF,” International Journal of Innovation and Scientific Research, vol. 12, no. 2, pp. 420–435, December 2014.
