ELECTROCHEMICAL BEHAVIOR OF CHLORAMPHENICOL AND ITS DETERMINATION USING CYCLIC VOLTAMETRY

Alemayehu, Tassew; SERGAWIE, ASSEFA

The author(s) of this article has(ve) requested that it be retracted from publication

Volume 8, Issue 2, September 2014, Pages 159–171

ELECTROCHEMICAL BEHAVIOR OF CHLORAMPHENICOL AND ITS DETERMINATION USING CYCLIC VOLTAMETRY

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@article{IJISR-14-178-03,
author = {Tassew Alemayehu and ASSEFA SERGAWIE},
title = {{ELECTROCHEMICAL BEHAVIOR OF CHLORAMPHENICOL AND ITS DETERMINATION USING CYCLIC VOLTAMETRY}},
journal = {International Journal of Innovation and Scientific Research},
volume = {8},
year = {2014},
pages = {159--171},
issue = {2},
number = {2},
issn = {2028-9324},
url = {http://www.ijisr.issr-journals.org/abstract.php?article=IJISR-14-178-03},
abstract_html_url = {http://www.ijisr.issr-journals.org/abstract.php?article=IJISR-14-178-03},
pdf_url = {http://www.issr-journals.org/xplore/ijisr/0008/002/IJISR-14-178-03.pdf},
document_type={Article},
source={www.issr-journals.org}
}

TY  - JOUR
ID  - 
TI  - ELECTROCHEMICAL BEHAVIOR OF CHLORAMPHENICOL AND ITS DETERMINATION USING CYCLIC VOLTAMETRY
AU  - Tassew Alemayehu
AU  - ASSEFA SERGAWIE
PY  - 2014
VL  - 8
IS  - 2
SP  - 159
EP  - 171
JO  - International Journal of Innovation and Scientific Research
T2  - International Journal of Innovation and Scientific Research
SN  - 20289324
UR  - http://www.ijisr.issr-journals.org/abstract.php?article=IJISR-14-178-03
AB  - This work uses a method that enhances the performance of glassy carbon electrode (GCE) for the determination of chloramphenicol (CAP). The electrochemical properties of chloramphenicol at electrochemically pretreated glassy carbon electrode were studied using cyclic voltammeter (CV). Electrochemical pretreatment of the electrode greatly enhanced the reduction peak current (Ip) of CAP. CAP shows an irreversible reduction peak at -0.674 V vs. Ag/AgCl at the GCE in 0.05 M acetate buffer of pH 5. Detailed experiments were carried out to establish the electrochemical property, the optimal buffer and its pH, electrode pretreatment potential, scan rate dependence study and effect of concentration. Following optimization pH of buffer solution, the peak current response for the reduction of CAP shows an enhanced response, 2.0 times greater than the bare GCE. A series of four CAP determination in 1.6 x 10-6 to 2 x 10-4 M concentration range show a linear calibration curve with r = 0.99997. At this range the limit of detection was LOD = 2.45 ?M with a standard deviation of SD = 0.03814. The method was successfully applied to three CAP containing pharmaceutical samples: CAP eye drop, CAP palmitat oral suspension and CAP as sodium succinate and the level of CAP in these samples was verified.
ER  -

TY  - JOUR
ID  - 
TI  - ELECTROCHEMICAL BEHAVIOR OF CHLORAMPHENICOL AND ITS DETERMINATION USING CYCLIC VOLTAMETRY
AU  - Tassew Alemayehu
AU  - ASSEFA SERGAWIE
PY  - 2014
VL  - 8
IS  - 2
SP  - 159
EP  - 171
JO  - International Journal of Innovation and Scientific Research
SN  - 20289324
AB  - 
This work uses a method that enhances the performance of glassy carbon electrode (GCE) for the determination of chloramphenicol (CAP). The electrochemical properties of chloramphenicol at electrochemically pretreated glassy carbon electrode were studied using cyclic voltammeter (CV). Electrochemical pretreatment of the electrode greatly enhanced the reduction peak current (Ip) of CAP. CAP shows an irreversible reduction peak at -0.674 V vs. Ag/AgCl at the GCE in 0.05 M acetate buffer of pH 5. Detailed experiments were carried out to establish the electrochemical property, the optimal buffer and its pH, electrode pretreatment potential, scan rate dependence study and effect of concentration. Following optimization pH of buffer solution, the peak current response for the reduction of CAP shows an enhanced response, 2.0 times greater than the bare GCE. A series of four CAP determination in 1.6 x 10-6 to 2 x 10-4 M concentration range show a linear calibration curve with r = 0.99997. At this range the limit of detection was LOD = 2.45 ?M with a standard deviation of SD = 0.03814. The method was successfully applied to three CAP containing pharmaceutical samples: CAP eye drop, CAP palmitat oral suspension and CAP as sodium succinate and the level of CAP in these samples was verified.
ER  -

RT Journal Article
ID IJISR-14-178-03
A1 Tassew Alemayehu
A1 ASSEFA SERGAWIE
YR 2014
T1 ELECTROCHEMICAL BEHAVIOR OF CHLORAMPHENICOL AND ITS DETERMINATION USING CYCLIC VOLTAMETRY
JF International Journal of Innovation and Scientific Research

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Tassew Alemayehu¹ and ASSEFA SERGAWIE²

¹ Department of Biology, Adigrat University, Adigrat, Tigray, P.Box. 50, Ethiopia
² College of natural and computational sciences, department of chemistry, Adis Abeba Inistitute Technology University, Adis Abeba, Ethiopia

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ELECTROCHEMICAL BEHAVIOR OF CHLORAMPHENICOL AND ITS DETERMINATION USING CYCLIC VOLTAMETRY