End stage renal disease (ESRD) is characterized by disorders of both the innate and adaptive systems. No study is available on disturbance of immune system in ESRD Moroccans patients under dialysis treatment. The aim of this study is to describe the immune status in these patient groups. Our results show the need for a further study in our patients, who are in a state of chronic inflammation following activation of complement, and immune dysfunction leading to impaired function of cells T, B and NK, accompanied by decreased production of antibodies. Understanding the mechanisms behind the immune dysfunction in ESRD generates a perspective to improve lifestyle and reduce mortality in this group of patients.