The objective of this research was to study the relationship between fatalistic beliefs, level of study and risk-taking of Cameroonians vis-à-vis COVID-19. Indeed, this pandemic that appeared in China towards the end of 2019 causes thousands of deaths around the world. In Cameroon, despite the many measures enacted by the Government, statistics indicate an evolution in the number of cases (nearly 20,000 cases, MINSANTE, 2020). Using the simple random sampling technique, 219 participants aged 18 to 63 were asked to complete a composite questionnaire (fatalistic belief scale, Shen et al., 2009; Protection Motivation Theory Scale, Rogers, 1973, sociodemographic variables). The results from the analysis of variances, correlations and regressions confirm our hypotheses. Overall, it is observed that the level of study influences fatalistic beliefs (F (2.115) = 5.83, p =.004) and risk-taking (F (2.115) = 9.29, p =.001). On the other hand, fatalistic beliefs explain the risk-taking vis-à-vis COVID-19 [r (219) = 0.175, p < 0.01; β = 0.175, t (217) = 2.613, p = 0.010, F (2.217) = 6.826, p = 0.010)]. Such results show the place of certain socio-demographic variables and fatalistic beliefs and the need to take them into account when addressing the issue of safety behavior.