Volume 31, Issue 1, June 2017, Pages 153–157
K. Kalakuko1, A. Sadiki2, El Kent Atumishi Mubangu3, L. Mazambi4, and M. Isumbisho5
1 Institut Supérieur des Techniques Médicales (I.S.T.M.) de Bukavu, RD Congo
2 Institut Supérieur des Techniques Médicales (I.S.T.M.) de Bukavu, RD Congo
3 Université Libre des Pays des Grands Lacs de Bukavu (ULPGL) de Bukavu, RD Congo
4 Institut Supérieur des Techniques Médicales (I.S.T.M.) de Bukavu, RD Congo
5 Unité d'Enseignement et de Recherche en Hydrobiologie Appliquée (U.E.R.H.A.), Dpt. de Biologie-Chimie, ISP/Bukavu, RD Congo
Original language: French
Copyright © 2017 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Introduction: The rapid diuretic furosemide is the temporary loop that is used in the states of edema associated so far in the liver, kidney and heart especially by oral and intravenous routes of administration but its quality control remains a problem in the administration of this drug in the DR Congo. Method: A cross sectional study was performed on three brands of furosemide 40mg sold in pharmacies Gerva Foundation More and Biosadec of Bukavu in the South Kivu Province. A sample of 60 tablets in the newly approved three pharmacies or 20 tablets per drug were dissolved in water as a solvent and analyzed by UV spectrophotometry at 270 nm to determine the concentrations of active ingredients. The Anova test at significance level 0.5 and linear regression using the Past version1.9.1 and Excel 2010 were used to compare quantitative variables. Result: Three brands of furosemide (New cesamex Techno economic services Frusina) Frusina shows slightly high test percentage of 99.6% and the two other marks techno economic services and New cesamex show respectively a percentage of the testing of 98 , 75%. A non-significant difference was observed between the three brands p> 0.05 with R2 = 0.99.
Author Keywords: Furosemide, UV spectrophotometry, Frusina, Techno economic services, New cesamex.
K. Kalakuko1, A. Sadiki2, El Kent Atumishi Mubangu3, L. Mazambi4, and M. Isumbisho5
1 Institut Supérieur des Techniques Médicales (I.S.T.M.) de Bukavu, RD Congo
2 Institut Supérieur des Techniques Médicales (I.S.T.M.) de Bukavu, RD Congo
3 Université Libre des Pays des Grands Lacs de Bukavu (ULPGL) de Bukavu, RD Congo
4 Institut Supérieur des Techniques Médicales (I.S.T.M.) de Bukavu, RD Congo
5 Unité d'Enseignement et de Recherche en Hydrobiologie Appliquée (U.E.R.H.A.), Dpt. de Biologie-Chimie, ISP/Bukavu, RD Congo
Original language: French
Copyright © 2017 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction: The rapid diuretic furosemide is the temporary loop that is used in the states of edema associated so far in the liver, kidney and heart especially by oral and intravenous routes of administration but its quality control remains a problem in the administration of this drug in the DR Congo. Method: A cross sectional study was performed on three brands of furosemide 40mg sold in pharmacies Gerva Foundation More and Biosadec of Bukavu in the South Kivu Province. A sample of 60 tablets in the newly approved three pharmacies or 20 tablets per drug were dissolved in water as a solvent and analyzed by UV spectrophotometry at 270 nm to determine the concentrations of active ingredients. The Anova test at significance level 0.5 and linear regression using the Past version1.9.1 and Excel 2010 were used to compare quantitative variables. Result: Three brands of furosemide (New cesamex Techno economic services Frusina) Frusina shows slightly high test percentage of 99.6% and the two other marks techno economic services and New cesamex show respectively a percentage of the testing of 98 , 75%. A non-significant difference was observed between the three brands p> 0.05 with R2 = 0.99.
Author Keywords: Furosemide, UV spectrophotometry, Frusina, Techno economic services, New cesamex.
Abstract: (french)
Introduction: Le furosemide est le diurétique rapide de la boucle provisoire qui est utilisé dans les états de l'œdème associés si loin dans l’insuffisance hépatique, rénale et particulièrement cardiaque par voies d'administration orales et intraveineuses mais son contrôle qualité demeure un problème dans l’administration de ce médicament en RD Congo. Méthode: Une étude transversale a été réalisée sur trois marques de furosémide 40mg vendues dans les pharmacies Gerva, Fondation Plus et Biosadec de la ville de Bukavu dans la Province du Sud-Kivu. Un échantillon de 60 comprimés nouvellement réceptionnés dans les trois pharmacies soit 20 comprimés par pharmacie, ont été dissous dans l’eau comme solvant puis analysés par spectrophotométrie UV à 270 nm afin de déterminer les concentrations des principes actifs. Le test Anova au seuil de signification 0,5 et la régression linéaire à l’aide des logiciels Past version1.9.1 et Excel 2010 ont été utilisés pour comparer les variables quantitatives. Résultat: De trois marques de furosémide (New cesamex, Techno economic services, Frusina), Frusina montre le pourcentage d’essai légèrement élevé de 99,6% et les deux autres marques techno economic services et New cesamex montrent respectivement un pourcentage d’essais de 98,75%. Une différence non significative a été observée entre les trois marques p>0,05 avec R2= 0,99.
Author Keywords: Furosemide, Spectrophotométrie UV, Frusina, Techno economic services, New cesamex.
How to Cite this Article
K. Kalakuko, A. Sadiki, El Kent Atumishi Mubangu, L. Mazambi, and M. Isumbisho, “ESSAI DU DOSAGE PAR SPECTROPHOTOMETRIE UV DU FUROSEMIDE VENDU A BUKAVU,” International Journal of Innovation and Scientific Research, vol. 31, no. 1, pp. 153–157, June 2017.
