[ Prévalence des anticorps anti-transglutaminases de type IgA de la maladie cœliaque chez des enfants diabétiques de type 1 ]
Volume 61, Issue 1, June 2022, Pages 17–21
Imad El Faiz1, Rachid El Faiz2, Asmaa Drissi Bourhanbour3, and Jalila El Bakkouri4
1 Laboratoire d’immunologie-sérologie, CHU Ibn Rochd Casablanca, Morocco
2 Laboratoire de biochimie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
3 Laboratoire d’immunologie-sérologie, CHU Ibn Rochd Casablanca, Morocco
4 Laboratoire d’Immunologie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
Original language: French
Copyright © 2022 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The prevalence of celiac disease in the general population is 1%, it is more common in patients with type 1 diabetes. Our objective is to determine the prevalence of anti-transglutaminase type IgA antibodies in children with type 1 diabetes. For this, we conducted a descriptive retrospective study, carried out within the laboratory of immunology-serology of the CHU Ibn Rochd of Casablanca. We included all requests for research of anti-transglutaminase type IgA antibodies in children with type 1 diabetes, over a period of 3 years. Our study identified 480 children with type 1 diabetes. The median age was 9 years with extremes of 1 to 14 years, 247 children were male or 51.5% versus 233 female or 48.5%, the sex ratio (M/F) calculated was 1.06. Anti-transglutaminase type IgA antibodies were positive in 70 patients, a prevalence of 14.6%. We compared the seropositive group (n=70) with the seronegative group (n=410). There was no difference between the two groups for age. However, female children were more affected in the seropositive group. This study confirms that celiac disease is common in diabetic patient’s type 1. Early diagnosis of celiac disease is very important to prevent long-term complications. These complications can be prevented by a simple gluten-free diet.
Author Keywords: Screening, Serology, Gluten, Auto-antibodies, Immunoglobulin-A.
Volume 61, Issue 1, June 2022, Pages 17–21
Imad El Faiz1, Rachid El Faiz2, Asmaa Drissi Bourhanbour3, and Jalila El Bakkouri4
1 Laboratoire d’immunologie-sérologie, CHU Ibn Rochd Casablanca, Morocco
2 Laboratoire de biochimie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
3 Laboratoire d’immunologie-sérologie, CHU Ibn Rochd Casablanca, Morocco
4 Laboratoire d’Immunologie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
Original language: French
Copyright © 2022 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The prevalence of celiac disease in the general population is 1%, it is more common in patients with type 1 diabetes. Our objective is to determine the prevalence of anti-transglutaminase type IgA antibodies in children with type 1 diabetes. For this, we conducted a descriptive retrospective study, carried out within the laboratory of immunology-serology of the CHU Ibn Rochd of Casablanca. We included all requests for research of anti-transglutaminase type IgA antibodies in children with type 1 diabetes, over a period of 3 years. Our study identified 480 children with type 1 diabetes. The median age was 9 years with extremes of 1 to 14 years, 247 children were male or 51.5% versus 233 female or 48.5%, the sex ratio (M/F) calculated was 1.06. Anti-transglutaminase type IgA antibodies were positive in 70 patients, a prevalence of 14.6%. We compared the seropositive group (n=70) with the seronegative group (n=410). There was no difference between the two groups for age. However, female children were more affected in the seropositive group. This study confirms that celiac disease is common in diabetic patient’s type 1. Early diagnosis of celiac disease is very important to prevent long-term complications. These complications can be prevented by a simple gluten-free diet.
Author Keywords: Screening, Serology, Gluten, Auto-antibodies, Immunoglobulin-A.
Abstract: (french)
La prévalence de la maladie cœliaque dans la population générale est de 1 %, elle est plus fréquente chez les patients atteints de diabète de type 1. Notre objectif est de déterminer la prévalence des anticorps anti-transglutaminases de type IgA chez des enfants diabétiques de type 1. Pour cela nous avons mené une étude rétrospective descriptive, réalisée au sein du laboratoire de d’immunologie-sérologie du CHU Ibn Rochd de Casablanca. Nous avons inclus toutes les demandes de recherche des anticorps anti-transglutaminases de type IgA chez des enfants diabétiques de type 1, sur une durée de 3. Notre étude a recensée 480 enfants diabétiques de type 1. La médiane d’âge était de 9 ans avec des extrêmes de 1 à 14 ans, 247 enfants étaient de sexe masculin soit 51,5% versus 233 de sexe féminin soit 48,5%, le sexe ratio (M/F) calculé était de 1,06. Les anticorps anticorps anti-transglutaminases de type IgA étaient positifs chez 70 patients soit une prévalence de 14,6%. Nous avons comparé le groupe séropositif (n=70) avec le groupe séronégatif (n=410). Il n’avait pas de différence entre les deux groupes pour l’âge. Cependant les enfants de sexe féminin étaient plus touchés dans le groupe des patients séropositifs. Cette étude confirme que la maladie cœliaque est fréquente chez les patients diabétiques de type 1. Le diagnostic précoce de la maladie cœliaque est très important pour prévenir les complications à long terme. Ces complications peuvent être prévenues par un simple régime sans gluten.
Author Keywords: Dépistage, Sérologie, Gluten, Auto-anticorps, Immunoglobuline-A.
How to Cite this Article
Imad El Faiz, Rachid El Faiz, Asmaa Drissi Bourhanbour, and Jalila El Bakkouri, “Prevalence of anti-transglutaminase type IgA antibodies in celiac disease in children with type 1 diabetes,” International Journal of Innovation and Scientific Research, vol. 61, no. 1, pp. 17–21, June 2022.
