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International Journal of Innovation and Scientific Research
ISSN: 2351-8014
 
 
Wednesday 25 May 2022

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Comparative study of the quality control of Ampicillin sold in Niamey city by Thin Layer Chromatography


Volume 57, Issue 1, October 2021, Pages 24–29

 Comparative study of the quality control of Ampicillin sold in Niamey city by Thin Layer Chromatography

Salifou Karimoune Fadjimata1, Zangui Hamissou2, Amadou Mounkaila Hamissou3, and Karimoun Massalatchi Illiyassou4

1 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
2 Department of vegetable production, Abdou Moumouni University, Faculty of agronomy, BP: 10960 Niamey, Niger
3 Department de Productions Végétales, Faculté d’Agronomie, Université Abdou Moumouni, BP: 10960 Niamey, Niger
4 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger

Original language: English

Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


The objective of this work is to demonstrate the quality of Ampicillin used alongside and in the health centers by the population of Niamey city by using Thin Layer Chromatography method to compare the results achieved in order to contribute to informed decision-making for possible interventions. This comparison aimed to investigate the quality of on eleven samples distributed as follows which five samples are from pharmacies, five samples are from street vendors and one sample specialty used as reference to check the quality control of them. The different reagents used are: Hydrochloric acid (HCl) 32-36%, acetone, distilled water, ethyl acetate and acetic acid. All samples migrated in proposed diluent. This shows that all samples contain the active ingredient substance of ampicillin. The percentage of the active ingredient were calculated as per protocol of Clarke’s analysis of drugs and poisons in chemistry guidelines. It varies from 89,46 to 94,73 for pharmacies and street vendors.According to the results of the different frontal reports, sixty percent of Ampicillin products purchased from each side contains the percentage of active ingredient recommended by WHO.This technique of quality control can be used for practical work or tutorial and laboratories where drug quality control mechanism is not often checked.

Author Keywords: Ampicillin, Thin Layer Chromatography, pharmacies, street vendors, Niamey.


How to Cite this Article


Salifou Karimoune Fadjimata, Zangui Hamissou, Amadou Mounkaila Hamissou, and Karimoun Massalatchi Illiyassou, “Comparative study of the quality control of Ampicillin sold in Niamey city by Thin Layer Chromatography,” International Journal of Innovation and Scientific Research, vol. 57, no. 1, pp. 24–29, October 2021.