The present study was conducted to determine whether gratitude can work as a protective factor against depressive (pessimistic) attributions that people make about their lives. The study had two hypotheses; one expecting a negative correlation between the two variables and second expecting gratitude to predict lesser depressive attributions. For this purpose a sample of 328 participants (161 men and 167 women), with ages ranging from 17 – 40 years (x ̅=22.88, SD=4.244) was taken from various universities of Karachi city. Depressive Attributions Questionnaire (DAQ) and Gratitude Questionnaire-Six Item Form (GQ-6) along with a demographic information questionnaire were administered. Findings, using IBM SPSS 21, showed that the two variables have significant moderate negative relationship (r (328) = -.293, p<.001) and Gratitude was found to be a significant predictor of reduced Depressive attributions (β= -.45, t = -5.533, p < .001). Gratitude also explained a significant proportion of variance in depressive attribution scores (R2 = .086, F (1, 326) = 30.614, p < .001). It is therefore concluded that the attitude of gratitude or thankfulness does reduce the pessimistic view people develop about their lives.