Combretum nigricans is a species of high socio-economic importance in West Africa and particularly in Burkina Faso. However, the strong anthropic pressure and the lack of knowledge on the different modes of regeneration constitute the main factors which hinder the stability of the stands of the species. The objective of this study was to evaluate the ability of C. nigricans for vegetative propagation. To do this, two modes of vegetative regeneration were tested, namely root and stem cuttings and air layering. The results show that C. nigricans does not respond to vegetative propagation by root cuttings. However, tests on aerial fragment cuttings show that time period has a highly significant effect (p< 0.001) on the ability of the cuttings to vegetatively recover. The survival of the cuttings is strongly influenced by the diameter of the fragments (p< 0.001) and also varies from one period to another. Air layering carried out in March (during vegetative rest) gave after 06 months of follow-up a success rate of 45% with a high success rate for branches 16 to 18 mm in diameter. These preliminary results show that it is possible to reproduce C. nigricans by stem cuttings and air layering. These results are promising and open interesting perspectives for the improvement of gum production in Burkina Faso.