Volume 11, Issue 1, October 2014, Pages 48–52
Manjusha Pandey1, Shailja Pant2, R.C. Pande3, K.P. Singh4, and Harshita Gupta5
1 Microbiology Department, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Principal and Head Department of Microbiology, Dolphin Paramedical Institute, Dehradun Uttarankhand, India
3 Ex. Professor and Head Department of Microbiology, Pathology and Blood Bank, Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
4 Professor, Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh, India
5 Research Assistant, Department of Pulmonary Medicine, King George's Medical University, Lucknow, Uttar Prades, India
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cytomegalovirus is one of the opportunistic infections associated with significantly high morbidity and mortality among patients living with immunodeficiency syndrome. Cytomegaloviruses (CMV) are deoxyribonucleic acid (DNA) viruses and are members of the Herpesviridae family CMV are recognized pathogens that cause community-acquired pneumonia (CAP) in compromised hosts. We investigated the prevalence of CMV among seropositive cases of human immunodeficiency virus (HIV) from Northern India. In this study we observed the relationship between CMV infections among the immunocompromised patients. This study carried out in Department of Microbiology, King George's Medical University (KGMU), Lucknow and Dolphin (PG) Institute of Biomedical and Natural Sciences, Dehradun, Uttarakhand, India. Total 250 HIV sero-positive cases were considered in study of CMV infection. HIV status was confirmed by Enzyme linked immunosorbent assay (ELISA) done at antiretroviral (ART) center, KGMU, Lucknow. CMV positivity was evaluated by CMV- IgG and IgM antibodies using ELISA kit. Among 250 HIV positive cases 10.4% were found positive for CMV- IgG where as 8.4% were positive for CMV- IgM however 1.2% were found to be positive for both CMV- IgG and CMV- IgM. Sero-prevalence of CMV IgG and IgM among HIV infected cases were 10.4% and 8.0% respectively. No significant difference was observed among gender and age group in CMV infection among HIV-positive cases.
Author Keywords: HIV, cytomegalovirus, CMV – IgG and IgM antibodies, ELISA.
Manjusha Pandey1, Shailja Pant2, R.C. Pande3, K.P. Singh4, and Harshita Gupta5
1 Microbiology Department, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Principal and Head Department of Microbiology, Dolphin Paramedical Institute, Dehradun Uttarankhand, India
3 Ex. Professor and Head Department of Microbiology, Pathology and Blood Bank, Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
4 Professor, Department of Microbiology, King George's Medical University, Lucknow, Uttar Pradesh, India
5 Research Assistant, Department of Pulmonary Medicine, King George's Medical University, Lucknow, Uttar Prades, India
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Cytomegalovirus is one of the opportunistic infections associated with significantly high morbidity and mortality among patients living with immunodeficiency syndrome. Cytomegaloviruses (CMV) are deoxyribonucleic acid (DNA) viruses and are members of the Herpesviridae family CMV are recognized pathogens that cause community-acquired pneumonia (CAP) in compromised hosts. We investigated the prevalence of CMV among seropositive cases of human immunodeficiency virus (HIV) from Northern India. In this study we observed the relationship between CMV infections among the immunocompromised patients. This study carried out in Department of Microbiology, King George's Medical University (KGMU), Lucknow and Dolphin (PG) Institute of Biomedical and Natural Sciences, Dehradun, Uttarakhand, India. Total 250 HIV sero-positive cases were considered in study of CMV infection. HIV status was confirmed by Enzyme linked immunosorbent assay (ELISA) done at antiretroviral (ART) center, KGMU, Lucknow. CMV positivity was evaluated by CMV- IgG and IgM antibodies using ELISA kit. Among 250 HIV positive cases 10.4% were found positive for CMV- IgG where as 8.4% were positive for CMV- IgM however 1.2% were found to be positive for both CMV- IgG and CMV- IgM. Sero-prevalence of CMV IgG and IgM among HIV infected cases were 10.4% and 8.0% respectively. No significant difference was observed among gender and age group in CMV infection among HIV-positive cases.
Author Keywords: HIV, cytomegalovirus, CMV – IgG and IgM antibodies, ELISA.
How to Cite this Article
Manjusha Pandey, Shailja Pant, R.C. Pande, K.P. Singh, and Harshita Gupta, “Prevalence of Cytomegalovirus infection among HIV sero-positive patients – Case Study from North India,” International Journal of Innovation and Scientific Research, vol. 11, no. 1, pp. 48–52, October 2014.
